The VitaPancreaticCancer formulation targets advanced pancreatic cancer through a highly synergistic mechanism involving cannabinoids, terpenes, and flavonoids, all encapsulated within a nanoemulsion system for enhanced bioavailability and precision targeting of cancer cells.

​3. Why VitaPancreaticCancer?

The VitaPancreaticCancer formulation targets advanced pancreatic cancer through a highly synergistic mechanism involving cannabinoids, terpenes, and flavonoids, all encapsulated within a nanoemulsion system for enhanced bioavailability and precision targeting of cancer cells.

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THC (Δ9-Tetrahydrocannabinol) exerts its anticancer effects primarily by binding to CB1 and CB2 receptors of the endocannabinoid system. Activation of these receptors triggers a cascade of intracellular signals, including the ceramide pathway, which promotes apoptosis in cancer cells. THC also inhibits cancer cell proliferation by inducing ER stress and the upregulation of p8 mRNA, a protein involved in stress responses leading to apoptosis.

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THCV (Tetrahydrocannabivarin) acts as a CB1 receptor antagonist at low concentrations and a partial agonist at higher doses, modulating the PI3K/Akt and MAPK pathways involved in cell survival and proliferation. Its ability to inhibit CB1 receptor activity plays a role in reducing cancer cell growth and controlling tumor metabolism.

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CBD (Cannabidiol) exhibits strong anti-inflammatory and anti-tumor properties. It inhibits ROS production and reduces NF-κB activation, which diminishes the pro-inflammatory environment that fosters tumor progression. CBD also blocks GPR55, a receptor linked to cancer cell migration, and modulates the expression of TRPV1 receptors, which further induces apoptosis in cancer cells.

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CBG (Cannabigerol) is a CB1 and CB2 receptor partial agonist and shows anti-tumor activity by inhibiting ERK1/2 phosphorylation, leading to reduced cancer cell proliferation. It also influences PPARγ expression, a key transcription factor that regulates lipid metabolism and induces cancer cell differentiation and apoptosis.

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CBC’s (Cannabichromene) anti-cancer properties stem from its ability to modulate the endocannabinoid system without directly binding to CB1 or CB2 receptors. Instead, it increases levels of anandamide, an endogenous cannabinoid, through inhibition of FAAH (Fatty Acid Amide Hydrolase), enhancing anti-inflammatory and apoptotic responses. CBC also displays anti-proliferative effects by suppressing the MAPK/ERK pathway.

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Limonene, a monoterpene, exhibits anticancer properties through the modulation of Ras signaling pathways, which are often mutated in pancreatic cancer. By inhibiting protein prenylation, limonene disrupts the anchoring of Ras proteins to the cell membrane, thereby reducing cell proliferation and inducing apoptosis. Limonene also has antioxidant properties, reducing oxidative stress and protecting normal cells from free radical damage.

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Kaempferol is a potent antioxidant and anti-inflammatory agent that modulates PI3K/Akt and NF-κB signaling pathways, key players in cancer cell survival and inflammation. It also inhibits VEGF expression, reducing tumor angiogenesis, and induces cell cycle arrest in the G2/M phase, halting the proliferation of cancer cells. Kaempferol's ability to modulate apoptotic pathways through the upregulation of Bax and the downregulation of Bcl-2 further enhances its role in tumor suppression.

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The nanoemulsion formulation enhances the bioavailability of these hydrophobic compounds by encapsulating them in nano-sized droplets (less than 200 nm). This allows for efficient absorption through the digestive system and better cellular uptake. The smaller particle size improves tissue penetration, particularly into pancreatic tumors, which are known for their dense stromal architecture. The nanoemulsion ensures a controlled release of cannabinoids, terpenes, and flavonoids, maintaining sustained therapeutic levels in the bloodstream and within tumor microenvironments.

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The entourage effect of cannabinoids, terpenes, and flavonoids amplifies the therapeutic efficacy of each component. For instance, cannabinoids like CBD reduce the psychoactive effects of THC while enhancing its anticancer properties, and limonene improves the absorption and synergistic interaction of cannabinoids. Together, these compounds modulate multiple molecular pathways such as PI3K/Akt, MAPK, NF-κB, and VEGF, ultimately leading to tumor cell apoptosis, inhibition of metastasis, and reduction of angiogenesis.

This multi-targeted approach not only makes VitaPancreaticCancer highly effective but also reduces side effects, enhancing patient safety by minimizing the required dosages of each component​.

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​4. Important Information Before Using VitaPancreaticCancer

Consult your doctor if any of the following apply to you:

• You are undergoing chemotherapy, radiotherapy, or immunotherapy for pancreatic cancer.

• You are taking other medications, particularly those metabolized by the liver (e.g., anticoagulants, antiepileptics, antidepressants), as interactions may occur.

• You are pregnant or breastfeeding. The safety of ingredients like THC, THCV, CBD, CBG, and CBC, during pregnancy or breastfeeding has not been fully established. Use during these periods should only be considered if advised by your physician based on a careful risk-benefit assessment.

• You have pre-existing medical conditions, such as liver, kidney, or cardiovascular diseases, as these may affect the safety and efficacy of the treatment.

 

Do not take VitaPancreaticCancer if:

• If you are allergic to cannabinoids or any of the other components of this product. 

• If you are taking beta-blocker drugs such as metoprolol it may potentiate the mechanism of action of the drug inducing hypotension, dizziness, weakness.

 

 

5.  How to take VitaPancreaticCancer?​

• Follow your doctor's instructions and the product label for dosage. 

• Swallow the capsule whole with water. 

• Do not exceed the recommended dosage.

The recommended dosage in adults is: 1 - 2 capsules daily for 8 weeks.

 

If you accidentally take more than the recommended dose, seek medical help immediately. Symptoms of overdose include nausea, vomiting, seizures, heart problems (such as irregular heartbeat or cardiac arrest), lung conditions, and altered mental status

 

Recommendations:

• If you miss a dose, don’t worry. Simply take your next dose at the regular scheduled time the following day. Avoid doubling up on doses to make up for the missed one.

• To help you remember, try to take VitaPancreaticCancer at the same time each day.

• Do not discontinue VitaPancreaticCancer without consulting your doctor, even if you begin to feel better. Consistent use is important for maintaining its therapeutic effects.

 

6. Possible side effects

• If you experience a skin rash or any allergic reactions such as itching, swelling of the lips or tongue, wheezing, or difficulty breathing, stop using the product immediately and seek medical advice as soon as possible.

• Common side effects (affecting more than 1 in 10 people) may include insomnia, headaches, diarrhea, nausea, and fatigue.

• Rare side effects may include elevated liver enzymes (AST, ALT, GGT), seizures, status epilepticus, gait disturbances, or abnormal behavior.

 

Reporting of adverse effects:

If you experience any type of adverse effect, consult your doctor, even if it is a possible adverse effect not listed in this datasheet. You can also report the effect directly via email.

By reporting adverse effects you can contribute to providing more information about the safety of this product.

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7. Storage of  VitaPancreaticCancer

• Keep this product out of the sight and reach of children.

• Do not use this product after the expiration date stated on the package. The expiration date is the last day of the month indicated.

• Store VitaPancreaticCancer softgels at a temperature below 30 ºC.

 

8. Package contents and additional information

Each capsule of VitaPancreaticCancer contains THC - 25 mg, THCV - 40 mg, CBD - 100 mg, CBG - 80 mg, CBC - 25 mg, limonene - 500 mg and kaempferol - 500 mg.

The other ingredients are: Medium Chain Triglycerides (MCT), Sorbitan 80 (Span 80), Vitamin E, Polysorbate 80 (Tween 80), and Polyethylene glycol 400.

 

Appearance of the product and package contents

The soft capsule is oval-shaped with a smooth, shiny surface and amber color.

The capsules are available in packs of 30, 60 or 90 capsules.

 

9. Disclaimer

The information provided here is based on extensive research conducted to develop VitaPancreaticCancer and its proposed mechanisms of action. However, this information is intended for informational purposes only and does not constitute medical advice.

These statements and products have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.